Publications

Human Papillomavirus Related Publications

Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas

Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Parthiban Marimuthu, Fang Cheng, Patrik C. Eklund & John Elias Eriksson. Scientific Reports 2019 9:20295  DOI: 10.1038/s41598-019-56410-1

Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic Simulations

Rajendran Senthilkumar, Parthiban Marimuthu, Preethy Paul, Yesaiyan Manojkumar, Sankaralingam Arunachalam, John E. Eriksson, and Mark S. Johnson. Journal of Chemical Information and Modeling 2016 56: 2401-2412 DOI: 10.1021/acs.jcim.6b00445

Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells

Preethy Paul, Senthil Kumar Rajendran, Emilia Peuhu, Ali A. Alshatwi, Mohammad A. Akbarsha, Sakari Hietanen, John E. Eriksson. Biochemical Pharmacology 2014 89: 171-184 DOI: 10.1016/j.bcp.2014.02.011

Heat Shock Factor Related Publications

Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions.

Anniina Vihervaara, Dig Bijay Mahat, Samu V. Himanen, Malin A.H. Blom, John T. Lis & Lea Sistonen. Molecular Cell 2021 DOI: 10.1016/j.molcel.2021.03.007

Molecular Mechanisms of Heat Shock Factors in Cancer

Mikael C. Puustinen & Lea Sistonen. Cells 2020 9(5):1202 DOI: 10.3390/cells9051202

Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

Jenny Joutsen, Alejandro J. Da Silva, Jens C. Luoto, Marek A. Budzyński, Anna S. Nylund, Aurelie de Thonel, Jean-Paul Concordet, Valérie Mezger, Délara Sabéran-Djoneidi, Eva Henriksson & Lea Sistonen. Cell Reports 2020 30(2):583-597.e6 DOI: 10.1016/j.celrep.2019.12.037

Tailoring of Proteostasis Networks with Heat Shock Factors

Jenny Joutsen & Lea Sistonen. Cold Spring Harbor Perspectives in Biology 2018 DOI: 10.1101/cshperspect.a034066

Heat-shock factor 2 is a suppressor of prostate cancer invasion

Johanna K. Björk, Malin Åkerfelt, Jenny Joutsen, Mikael C. Puustinen, Fang Cheng, Lea Sistonen & Matthias Nees. Oncogene 2016 35(14):1770-84 DOI: 10.1038/onc.2015.241

Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival.

Alexandra N. Elsing, Camilla Aspelin, Johanna K. Björk, Heidi A. Bergman, Samu V. Himanen, Marko J. Kallio, Pia Roos-Mattjus & Lea Sistonen. J Cell Biol. 2014 206(6):735-49 DOI: 10.1083/jcb.201402002

Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells

Anniina Vihervaara, Christian Sergelius, Jenni Vasara, Malin A.H. Blom, Alexandra N. Elsing, Pia Roos-Mattjus & Lea Sistonen. Proceedings of the National Academy of Sciences of the United States of America 2013 110(36):E3388-97 DOI: 10.1073/pnas.1305275110